Drostanolone propionate is an anabolic steroid derived from dihydrotestosterone (DHT). It is commonly known by its brand name Masteron. Drostanolone propionate is primarily used in bodybuilding and athletic circles rather than in medical settings due to its specific properties and effects.

Medical Uses

Drostanolone propionate has limited approved medical uses:

1. Breast Cancer: It has been used in the treatment of advanced breast cancer in women who have failed other therapies. It acts as an anti-estrogenic agent, potentially reducing estrogen levels and inhibiting tumor growth.

Mechanism of Action

Drostanolone propionate exerts its effects through several mechanisms:

• Androgen Receptor Binding: It binds strongly to androgen receptors in various tissues, promoting anabolic effects such as muscle growth and increased strength.
• Anti-Estrogenic Effects: Acts as an anti-estrogenic agent, potentially reducing estrogen levels in the body.
• Protein Synthesis: Enhances protein synthesis, contributing to muscle mass preservation and potential gains.
• Nitrogen Retention: Promotes nitrogen retention in muscles, crucial for muscle growth and recovery.

Side Effects

While effective, drostanolone propionate can have several potential side effects:

1. Androgenic Effects: May cause increased body hair growth, acne, and deepening of the voice.
2. Cardiovascular Issues: Can lead to adverse effects on cholesterol levels and increased blood pressure.
3. Liver Toxicity: Although less hepatotoxic than some oral steroids, injectable forms can still stress the liver to some degree.
4. Reproductive Effects: Suppression of natural testosterone production, which can lead to testicular atrophy and infertility.

Interactions

Drostanolone propionate may interact with medications affecting liver function or those that alter hormonal balance. Specific interactions may include:

• Aromatase Inhibitors: These drugs can alter the metabolism of drostanolone propionate.
• Selective Estrogen Receptor Modulators (SERMs): They can interact with drostanolone propionate, impacting its effectiveness and the body’s hormonal balance.
• 5-Alpha Reductase Inhibitors: These medications can influence the androgenic activity of drostanolone propionate.
• Anti-Androgens: These drugs can counteract some of the effects of drostanolone propionate.