Drostanolone enanthate is an injectable anabolic steroid derived from dihydrotestosterone (DHT), known for its potent androgenic effects and moderate anabolic properties. It is less commonly used in medical settings compared to its propionate counterpart, primarily due to its specific characteristics and limited approved uses.

Medical Uses

Drostanolone enanthate has limited medical uses and is primarily employed for:

1. Breast Cancer: Similar to drostanolone propionate, it has been used experimentally in the treatment of advanced breast cancer in women who have failed other therapies. Its anti-estrogenic properties are thought to inhibit estrogen-dependent tumor growth.

Mechanism of Action

Drostanolone enanthate exerts its effects through several mechanisms:

• Androgen Receptor Binding: Binds strongly to androgen receptors in various tissues, promoting androgenic effects such as increased muscle hardness and density.
• Anti-Estrogenic Effects: Acts as an anti-estrogenic agent, potentially reducing estrogen levels in the body, which is beneficial in breast cancer treatment.
• Protein Synthesis: Enhances protein synthesis, contributing to muscle mass preservation and potential gains, albeit less pronounced compared to some other steroids.
• Nitrogen Retention: Promotes nitrogen retention in muscles, crucial for muscle growth and recovery.

Side Effects

While effective, drostanolone enanthate can have potential side effects:

1. Androgenic Effects: May cause increased body hair growth, acne, and deepening of the voice.
2. Cardiovascular Issues: Can lead to adverse effects on cholesterol levels and potentially increase blood pressure.
3. Liver Toxicity: Although less hepatotoxic than some oral steroids, injectable forms can still stress the liver to some degree.
4. Reproductive Effects: Suppression of natural testosterone production, which can lead to testicular atrophy and infertility.

Interactions

Drostanolone enanthate may interact with medications affecting liver function or those that alter hormonal balance. Specific interactions may include:

• Aromatase Inhibitors: These drugs can alter the metabolism of drostanolone enanthate.
• Selective Estrogen Receptor Modulators (SERMs): They can interact with drostanolone enanthate, impacting its effectiveness and the body’s hormonal balance.
• 5-Alpha Reductase Inhibitors: These medications can influence the androgenic activity of drostanolone enanthate.
• Anti-Androgens: These drugs can counteract some of the effects of drostanolone enanthate.